| Health / Medical Topics |
Sofosbuvir
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome. (NCI Thesaurus)
YOU MAY ALSO LIKE
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2 (208 aa, ~24 kDa) is encoded by the human NKAIN2 gene. This protein may play a…
Sodium/nucleoside cotransporter 2 (658 aa, ~72 kDa) is encoded by the human SLC28A2 gene. This protein is involved in purine nucleoside…
Sodium/nucleoside cotransporter 1 (649 aa, ~72 kDa) is encoded by the human SLC28A1 gene. This protein is involved in sodium-mediated transport of…
Sodium/glucose cotransporter 1 (644 aa, ~73 kDa) is encoded by the human SLC5A1 gene. This protein is involved in the active transport…
An integral membrane transport protein. Expression of the sodium/iodide symporter (NIS) is high in lactating mammary tissue and in over 80%…
Sodium-dependent serotonin transporter (630 aa, ~70 kDa) is encoded by the human SLC6A4 gene. This protein is involved in serotonin internalization. …
