Somatostatin Receptor

Definition 1

Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin receptor scintigraphy has been one of the most important diagnostic tools for staging of Neuroendocrine gastrointestinal tumors and also indicating sensitivity to treatment with somatostatin analogues. This marker can be used for diagnosis and follow-up of the patients. (from Ann Oncol 1999;10 Suppl 2:S3-8) (NCI Thesaurus)

Definition 2

Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin is a hypothalamic hormone, a pancreatic hormone, and a central and peripheral neurotransmitter. Activated somatostatin receptors on pituitary cells inhibit the release of growth hormone; those on endocrine and gastrointestinal cells regulate the absorption and utilization of nutrients; and those on neurons mediate somatostatin's role as a neurotransmitter. (NLM, Medical Subject Headings)

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