Spectrin SH3 Domain Binding Protein 1

Encoded by human SSH3BP1 Gene, Spectrin SH3 Domain Binding Protein 1 contains similarity to homeotic proteins, several polyproline stretches, and a C terminal SH3 domain required for binding to ABL proteins. Binding SH3 domains of EPS8, SSH3BP1 adaptor protein holds EGFR substrate EPS8 in complex with SOS1, mediating RAS signal transduction to RAC (activation) by regulating RAC-specific GEF activity. Depending on its association with SSH3BP1 or RNTRE, EPS8 participates in EGFR signaling through RAC or in EGFR trafficking through RAB5. EPS8 interacts through its SH3 domain with the EGFR-regulated RAB5 GAP RNTRE, which inhibits EGFR internalization. EPS8 diversion from RAC-activation by RNTRE, results in RAC signaling attenuation. (NCI Thesaurus)

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