Src/Abl Kinase Inhibitor AZD0424

An orally bioavailable small molecule tyrosine kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Upon oral administration, AZD0424 selectively inhibits both Src and Abl kinase activity which may result in the inhibition of tumor growth in susceptible tumor cells. Src and Abl kinases are upregulated in certain tumor cells and play important roles in tumor cell proliferation and metastasis. (NCI Thesaurus)

YOU MAY ALSO LIKE

SRC wt Allele

Human SRC wild-type allele is located within 20q12-q13 and is approximately 61 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase…

SRC Tyrosine Kinase Activation Pathway

Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads…

Src Kinase Inhibitor KX2-391

An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding…

SRC Gene

This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions.

SRC Family Tyrosine Kinase

The SRC family tyrosine kinases are a class of non-receptor protein-tyrosine kinases that exhibit amino acid sequence similarity with SRC and participate…

SRC Family Oncogene

Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which encode diverse SRC Family Tyrosine Kinases, closely related intracellular…