SRC wt Allele

Human SRC wild-type allele is located within 20q12-q13 and is approximately 61 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase Src protein, plays a role in signal transduction pathways involved in the inhibition of endothelial cell apoptosis, regulation of the actin cytoskeleton, and the production of gonadotropins in pituitary cells. An allelic variant of the SRC gene, which produces a truncated, inactive protein, is associated with the development and metastasis of both breast and colon cancer. (NCI Thesaurus)

YOU MAY ALSO LIKE

SRC Tyrosine Kinase Activation Pathway

Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads…

Src Kinase Inhibitor KX2-391

An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding…

SRC Gene

This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions.

SRC Family Tyrosine Kinase

The SRC family tyrosine kinases are a class of non-receptor protein-tyrosine kinases that exhibit amino acid sequence similarity with SRC and participate…

SRC Family Oncogene

Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which encode diverse SRC Family Tyrosine Kinases, closely related intracellular…

SRC Family Gene

A family of genes that encode structurally similar non-receptor tyrosine kinases that play a role in intracellular signaling. Mutation of genes in…