SRD5A2 wt Allele

Human SRD5A2 wild-type allele is located within 2p23 and is approximately 56 kb in length. This allele, which encodes 3-oxo-5-alpha-steroid 4-dehydrogenase 2 protein, plays a role in the oxidation of androgens into their corresponding 5-alpha-3-oxosteroids. Specific heritable defects in the SRD5A2 gene are the cause of pseudovaginal perineoscrotal hypospadias. A specific allelic variant of this gene is associated with an increased risk of prostate cancer. (NCI Thesaurus)

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SRD5A2 Gene

This gene is involved in androgen metabolism and sexual differentiation.

SRD5A1 wt Allele

Human SRD5A1 wild-type allele is located 5p15 and is approximately 36 kb in length. This allele, which encodes 3-oxo-5-alpha-steroid 4-dehydrogenase 1 protein,…

SRD5A1 Gene

This gene is involved in the metabolism of androgens.

Src/Abl Kinase Inhibitor AZD0424

An orally bioavailable small molecule tyrosine kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Upon oral administration,…

SRC wt Allele

Human SRC wild-type allele is located within 20q12-q13 and is approximately 61 kb in length. This allele, which encodes proto-oncogene tyrosine-protein kinase…

SRC Tyrosine Kinase Activation Pathway

Progression through the cell cycle is accompanied by activation of the proto-oncogene c-Src, a protein tyrosine kinase. Overexpression of Src leads…