SS1(dsFv)-PE38 Immunotoxin

A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The monoclonal antibody moiety of the agent binds to cells that express mesothelin, a cell surface glycoprotein which may be overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas; after internalization, the exotoxin moiety inactivates eukaryotic translation elongation factor 2, thereby disrupting tumor cell protein synthesis. (NCI Thesaurus)

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Derived by Rapp from a colony of Sprague-Dawley rats that were initially derived by LK Dahl at Brookhaven National Laboratories. The SS…

SRY wt Allele

Human SRY wild-type allele is located in the vicinity of Yp11.3 and is approximately 1 kb in length. This allele, which encodes…

SRY Gene

This gene is involved in testis development and may be involved in transcription.

SRSF3 wt Allele

Human SRSF3 wild-type allele is located in the vicinity of 6p21 and is approximately 10 kb in length. This allele, which encodes…

SRSF3 Gene

This gene plays a role in RNA splicing and export.

SRSF2 wt Allele

Human SRSF2 wild-type allele is located in the vicinity of 17q25.1 and is approximately 4 kb in length. This allele, which encodes…