| Health / Medical Topics |
Stanniocalcin 1
Expressed in most tissues (ovary, prostate, heart, kidney, and thyroid highest) by human STC1 Gene (Stanniocalcin Family), 247-aa 28-kDa (precursor) secreted Stanniocalcin 1 is a homodimeric 35-kD glycoprotein hormone involved in calcium homeostasis and renal phosphate reabsorption. In kidney, expression is confined to the distal convoluted tubule and the collecting tubule. STC1 is 96% identical to mouse protein and 73% similar to fish STC. Serine phosphorylation by PKC may regulate activity. Ovarian STC may signal between thecal-interstitial cells and the corpus luteum and oocyte. (NCI Thesaurus)
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