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SUBSTRATE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An indigenous language that contributes features to the language of an invading people who impose their language on the indigenous population
Example:
the Celtic languages of Britain are a substrate for English
Synonyms:
substrate; substratum
Classified under:
Nouns denoting communicative processes and contents
Hypernyms ("substrate" is a kind of...):
indigenous language (a language that originated in a specified place and was not brought to that place from elsewhere)
Sense 2
Meaning:
Any stratum or layer lying underneath another
Synonyms:
substrate; substratum
Classified under:
Nouns denoting spatial position
Hypernyms ("substrate" is a kind of...):
stratum (one of several parallel layers of material arranged one on top of another (such as a layer of tissue or cells in an organism or a layer of sedimentary rock))
Sense 3
Meaning:
A surface on which an organism grows or is attached
Example:
the gardener talked about the proper substrate for acid-loving plants
Synonyms:
substrate; substratum
Classified under:
Nouns denoting spatial position
Hypernyms ("substrate" is a kind of...):
surface (the extended two-dimensional outer boundary of a three-dimensional object)
Sense 4
Meaning:
The substance that is acted upon by an enzyme or ferment
Classified under:
Hypernyms ("substrate" is a kind of...):
substance (the real physical matter of which a person or thing consists)
Context examples:
This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation.
(Pamidronic Acid, NCI Thesaurus)
Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death.
(Parkinson's Disease Pathway BioCarta, NCI Thesaurus/BIOCARTA)
A type of enzyme immunoassay that uses antigen-coated microparticles as a substrate for antibody binding.
(Microparticle Enzyme Immunoassay, NCI Thesaurus)
Schwannomin interacts with the HGF-regulated tyrosine kinase substrate HRS.
(Merlin, NCI Thesaurus)
Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates.
(MELK Inhibitor OTS167, NCI Thesaurus)
It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate (IP3) and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase.
(Phosphatidylinositol 4,5-bisphosphate, NCI Thesaurus)
This agent appears to not be a substrate for the p-glycoprotein associated multidrug-resistance (MDR) transporter; therefore, overcoming the resistance pattern seen with other anthracycline compounds.
(Annamycin, NCI Thesaurus)
Miglustat can be used in substrate reduction therapy in diseases in which the enzyme glucocerebrosidase, that is responsible for the breakdown of GSL, is deficient.
(Miglustat, NCI Thesaurus)
A measure of the rate at which a substrate can pass water.
(Permeability, NCI Thesaurus)
The oxidized substrate is regarded as a hydrogen donor.
(Oxidoreductase Gene, NCI Thesaurus)
