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Sulfonamide Anti-Infective Agent
Definition 1
A class of natural or synthetic sulfanilamide derivatives with antibacterial activity. Sulfonamides are structural analogs of para-aminobenzoic acid (essential for microbial folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA for dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis. (NCI Thesaurus)
Definition 2
A type of antibiotic used to treat infection. (NCI Dictionary)
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