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SUPPRESSOR GENE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A gene that suppresses the phenotypic expression of another gene (especially of a mutant gene)
Synonyms:
suppresser; suppresser gene; suppressor; suppressor gene
Classified under:
Hypernyms ("suppressor gene" is a kind of...):
cistron; factor; gene ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity)
Hyponyms (each of the following is a kind of "suppressor gene"):
tumor suppressor gene (a suppressor gene that blocks unscheduled cell division)
Context examples:
Hsp70 plays a significant role in protein unfolding for entry into mitochondria and also interacts with tumor suppressor gene products to produce their anti-proliferative activity.
(Interferon Signaling Modulation Pathway, NCI Thesaurus/BIOCARTA)
In addition, antineoplastons may inhibit RAS oncogene expression and activate the tumor suppressor gene p53, resulting in cell differentiation and apoptosis.
(Antineoplaston Agent, NCI Thesaurus)
Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis.
(Antineoplaston A10, NCI Thesaurus)
Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity.
(Dihydro-5-Azacytidine, NCI Thesaurus)
The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN.
(Melanoma Pathway, NCI Thesaurus/KEGG)
Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1.
(Non-Small Cell Lung Cancer Pathway, NCI Thesaurus/KEGG)
An autosomal dominant disorder caused by mutations in the NF2 tumor suppressor gene.
(Neurofibromatosis type 2, NCI Thesaurus)
Further, nanaomycin A may have antineoplastic properties resulting from a reduction in DNA methylation by inhibiting DNA methyltransferase 3B (DNMT3B) and reactivating the tumor suppressor gene RASSF1A.
(Nanafrocin, NCI Thesaurus)
Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1.
(Multiple Endocrine Neoplasia Type 1, NCI Thesaurus)
In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53.
(HDAC inhibitor CG200745, NCI Thesaurus)
