Syk-JAK Inhibitor PRT062070

An orally bioavailable dual inhibitor of spleen tyrosine kinase (Syk) and Janus-associated kinases (JAK), with potential anti-inflammatory and antineoplastic activity. Upon oral administration, Syk-JAK inhibitor PRT062070 specifically binds to and inhibits the activity of Syk, JAK1, and JAK3 with preferential inhibition of JAK1 and JAK3-dependent cytokine-mediated signaling and functional responses. This negatively affects the downstream JAK-STAT (signal transducer and activator of transcription) pathway, and leads to both reduced inflammation in various animal models and enhanced antiproliferative activity towards non-Hodgkin's lymphoma (NHL) cell lines. Syk is a non-receptor cytoplasmic tyrosine kinase involved in signal transduction in cells of hematopoietic origin including B cells, macrophages, basophils and neutrophils. Abnormal function of Syk has been implicated in several hematopoietic malignancies including NHL and chronic lymphocytic leukemia (CLL). The JAK-STAT pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. (NCI Thesaurus)

YOU MAY ALSO LIKE

SYK wt Allele

Human SYK wild-type allele is located within 9q22 and is approximately 94 kb in length. This allele, which encodes tyrosine-protein kinase SYK…

Syk kinase inhibitor R-935788

A substance being studied in the treatment of cancer and certain other diseases, such as rheumatoid arthritis. It may block tumor cell…

SYK Gene

This gene plays a role in receptor tyrosine phosphorylation signal transduction, phagocytosis, endothelial cell growth and proliferation.

syk Family Tyrosine Kinase

The syk family tyrosine kinases are non-receptor protein tyrosine kinases structurally similar to the syk protein (spleen tyrosine kinase) containing two SH2…

SY Term Type

The NCI term type designation for a synonym.

SX

Marker studies not available or not performed. (AJCC 7th ed.)