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Synaptophysin Staining Method
This is an immunohistochemical technique utilizing antibody to synaptophysin, an integral membrane glycoprotein present in presynaptic vesicles in neurons. The antibody labels neuroendocrine cells and neurons of the brain, spinal cord and retina. Used to detect neuroendocrine neoplasms including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas. (NCI Thesaurus)
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An immunophenotypic test result indicating positive staining of neoplastic cells for synaptophysin.
Samples counterstained with hematoxylin following Synaptophysin staining.
Synaptophysin (313 aa, ~34 kDa) is encoded by the human SYP gene. This protein is involved in the targeting of synaptic…
Synaptic vesicular amine transporter (514 aa, ~56 kDa) is encoded by the human SLC18A2 gene. This protein plays a role in pumping…
Reliable neurotransmitter release requires the presence of sufficient numbers of synaptic vesicles. The process of synaptic vesicle endocytosis (SVE) is coordinated…
The postsynaptic density (PSD) is a submembranous structure at the postsynaptic membrane mainly at the excitatory synapses. The neurotransmitter receptors are assembled…
