Library / English Dictionary

SYNERGISTICALLY

Pronunciation (US):

(GB):

 I. (adverb) 

Sense 1

Meaning:

(of drugs or muscles) in a synergistic or interactive manner

Classified under:

Adverbs

Pertainym:

synergistic (used especially of drugs or muscles that work together so the total effect is greater than the sum of the two (or more))

Sense 2

Meaning:

(of group) in a synergistic or cooperative manner

Classified under:

Adverbs

Pertainym:

synergistic (working together; used especially of groups, as subsidiaries of a corporation, cooperating for an enhanced effect)

Credits

 Context examples: 

In EBV-related lymphomas, arginine butyrate induces EBV thymidine kinase transcription and may act synergistically with the antiviral agent ganciclovir to inhibit cell proliferation and decrease cell viability.

(Arginine butyrate, NCI Thesaurus)

IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(IAP Inhibitor HGS1029, NCI Thesaurus)

The scientists carefully selected clinically approved drugs that work synergistically.

(Antibiotic Combinations May Combat MRSA Infections, NIH)

AT-406 may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis.

(IAP Inhibitor AT-406, NCI Thesaurus)

The researchers noted that because opioid and non-opioid mechanisms of pain relief interact synergistically, the results of this study suggest that combining mindfulness-based and pharmacologic/nonpharmacologic pain-relieving approaches that rely on opioid signaling may be particularly effective in treating pain.

(Scientists discover non-opioid pain pathway in the brain, NIH)

Synergistically, IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.

(Adenovirus-mediated Human Interleukin-12, NCI Thesaurus)

The cytokines in IRX-2, including interleukin (IL)-1, -2, -6, -8, -10, -12, tumor necrosis factor alpha (TNF-a), interferon-gamma (IFN-g) and colony stimulating factors (CSFs), play vital roles in regulating cellular immunity and may synergistically stimulate a cellular immune response against tumor cells.

(IRX-2, NCI Thesaurus)

Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus enhances antigen presentation, promotes natural killer (NK) cell-mediated killing and causes a cytotoxic T cell (CTL) response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.

(GM-CSF-encoding Oncolytic Adenovirus CGTG-102, NCI Thesaurus)