Synuclein Family

Small, soluble Synuclein Family proteins are a group of highly conserved post-transcriptionally modified Alpha, Beta, and Gamma proteins expressed primarily in neural tissue and often localized near synaptic vesicles. Synucleins may inhibit PLD2 and regulate vesicular transport. In the N-terminal portion, synucleins have a conserved repeated 11-residue amphipathic alpha-helical motif similar to the lipid-binding A2 domain of apolipoproteins. Synucleins also contain several repeated variations of a highly conserved KTKEGV domain, also present in rho family proteins. In brain, synucleins may be phosphorylated by Ca2+ calmodulin protein kinase II. Synucleins are overexpressed in breast carcinomas and mutations are associated with neurodegenerative illnesses. (NCI Thesaurus)

YOU MAY ALSO LIKE

Synthetic Scaffold Production

Creation of a synthetic, biocompatible scaffold for the generation of bioengineered structures.

Synthetic retinoid

A substance related to vitamin A that is produced in a laboratory.

Synthetic protegrin analog

A form of a protegrin that is made in the laboratory. Protegrins kill certain bacteria, fungi, and viruses by making holes in…

Synthetic Polymer

Synthetic high molecular weight molecules made up of a linked series of repeated monomeric subunits. The monomers can be of the same…

Synthetic Peptides E-PRA And E-PSM Vaccine

A cancer vaccine consisting of E-PRA and E-PSM, two synthetic peptide analogs of PRAME (PReferential Antigen MElanoma) and PSMA (Prostate Specific Membrane…

Synthetic Peptide Synthesis

The process of producing peptides by the polymerization of amino acids.