Synuclein Gamma

Encoded by human SNCG Gene (Synuclein Family), the highly conserved 127-amino acid 13 kD cytoplasmic Gamma-Synuclein is similar to the amyloid protein nonamyloid beta fragment and to alpha-synuclein and beta-synuclein. SNCG is expressed in brain, heart, skeletal muscle, ovary, testis, colon, spleen, pancreas, kidney and lung. Gamma-Synuclein seems to play a role in neurofilament network integrity and may modulate axonal architecture; it may increase the susceptibility of neurofilament-H to calcium-dependent proteases and may also modulate the keratin network in skin. Phosphorylation by GRK5 appears to occur on residues distinct from other kinase target residues. Gamma-Synuclein is likely involved in the pathogenesis of neurodegenerative diseases and SNCG is expressed at very high level in advanced infiltrating breast cancer. (from Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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