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T CELL
I. (noun)
Sense 1
Meaning:
A small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
Synonyms:
Classified under:
Hypernyms ("T cell" is a kind of...):
lymph cell; lymphocyte (an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection)
Hyponyms (each of the following is a kind of "T cell"):
CD4 cell; CD4 T cell; helper cell; helper T cell (T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus)
CD8 cell; CD8 T cell; cytotoxic T cell; killer cell; killer T cell (T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it)
Context examples:
Alefacept is made by combining part of an antibody with a protein that blocks the growth some types of T cells.
(Alefacept, NCI Dictionary)
In addition, this agent may induce antibody-dependent cell-mediated cytotoxicity (ADCC) against CCR4-positive T cells.
(Mogamulizumab, NCI Thesaurus)
Donor T cell therapy may help control transplant-related viral infections following allogeneic hematopoietic stem cell transplantation.
(Allodepleted Haploidentical T Cells-expressing Inducible Caspase 9, NCI Thesaurus)
This protein plays a role in T cell activation and serine/threonine phosphorylation.
(Mitogen-Activated Protein Kinase Kinase Kinase 8, NCI Thesaurus)
Agatolimod selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens.
(Agatolimod Sodium, NCI Thesaurus)
A murine monoclonal antibody that recognizes CD7 (previously known as 3A1), a cell surface antigen expressed by most normal mature peripheral T cells and T cell acute lymphoblastic leukemias.
(Monoclonal Antibody 3A1, NCI Thesaurus)
Alteration in the expression of this gene is associated with development of carcinomas of the liver, lung and stomach as well as multiple myeloma, and HTLV-related T cell leukemia.
(MIR93 wt Allele, NCI Thesaurus)
Also called MART-1 antigen and Melanoma Antigen Recognized by T cells 1.
(Melan-A protein, NCI Dictionary)
MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A) is a self antigen expressed on melanocytes and the retina.
(Melan-A, NCI Thesaurus)
Vaccines using pieces of the Melanoma Antigen Recognized by T cells 1 are being studied for their ability to boost the immune response to cancer cells in patients with melanoma.
(Melanoma Antigen Recognized by T cells 1, NCI Dictionary)
