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T-Cell Receptor Interacting Molecule
Expressed in T cells (not B cells or monocytes) of the thymus, spleen, lymph nodes, and peripheral leukocytes by human TRIM Gene, 186-aa 29/30-kD disulfide-linked dimeric type III transmembrane adaptor phosphoprotein T-Cell Receptor Interacting Molecule contains an 8-aa extracellular domain (includes a Cys residue), a 19-aa transmembrane region and an intracellular domain with 4 potential phosphorylation sites likely involved in SH2-mediated interactions with signaling proteins. Associated with CD3E and CD3Z, TRIM modulates the TCR-CD3 complex in T lymphocytes. After T-cell activation, TRIM is tyrosine phosphorylated by Src kinases and associates with PIK3R1. (NCI Thesaurus)
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