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T LYMPHOCYTE
I. (noun)
Sense 1
Meaning:
A small lymphocyte developed in the thymus; it orchestrates the immune system's response to infected or malignant cells
Synonyms:
Classified under:
Hypernyms ("T lymphocyte" is a kind of...):
lymph cell; lymphocyte (an agranulocytic leukocyte that normally makes up a quarter of the white blood cell count but increases in the presence of infection)
Hyponyms (each of the following is a kind of "T lymphocyte"):
CD4 cell; CD4 T cell; helper cell; helper T cell (T cell with CD4 receptor that recognizes antigens on the surface of a virus-infected cell and secretes lymphokines that stimulate B cells and killer T cells; helper T cells are infected and killed by the AIDS virus)
CD8 cell; CD8 T cell; cytotoxic T cell; killer cell; killer T cell (T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it)
Context examples:
Autologous vaccination with these altered dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for NA17, resulting in decreased tumor growth.
(NA17 Peptide (Amino acid sequence VLPDVFIRCV), NCI Thesaurus)
Vaccination with NY-ESO-1 peptide vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response to cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis.
(NY-ESO-1 Peptide Vaccine, NCI Thesaurus)
HIV infects white blood cells known as T lymphocytes, particularly the CD4+ T cells that recognise infection and gets the immune system to respond.
(HIV seeks refuge in immune cells to avoid full elimination, SciDev.Net)
Upon administration, mesothelioma tumor lysate-pulsed autologous dendritic cell vaccine may stimulate the host immune system to mount a specific cytotoxic T lymphocyte (CTL) response against mesothelioma tumor cells, resulting in tumor cell lysis.
(Mesothelioma Tumor Lysate-Pulsed Autologous Dendritic Cell Vaccine, NCI Thesaurus)
This leads to an activation of natural killer cells and cytotoxic T lymphocytes and to interferon gamma (INF-g) synthesis, thereby attaining an anti-angiogenic effect.
(Mycobacterial Cell Wall-DNA Complex, NCI Thesaurus)
Upon administration, Melan-A VLP vaccine may activate the immune system to exert a specific cytotoxic T lymphocyte (CTL) response against cancer cells expressing the Melan A antigen, resulting in tumor cell lysis.
(Melan-A VLP Vaccine, NCI Thesaurus)
Upon administration, MUC1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the MUC1 antigen, resulting in decreased tumor growth.
(MUC-1 Peptide Vaccine, NCI Thesaurus)
Vaccination with ALVAC-CEA (VCP248) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against CEA-positive tumor cells, thereby decreasing tumor growth.
(ALVAC-CEA (VCP248), NCI Thesaurus)
Upon administration, ALVAC-ESO-1 vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against NY-ESO-1-expressing cancer cells, which may result in the inhibition of tumor cell proliferation.
(ALVAC-ESO-1 Vaccine, NCI Thesaurus)
A recombinant monoclonal antibody directed against human T-cells designed to generate cytotoxic T lymphocyte (CTL) responses to tumor antigens with potential use in cancer immunotherapy.
(Monoclonal Antibody 95-6-22, NCI Thesaurus)
