Tacrolimus

Pronunciation

Definition 1

A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants. (NCI Dictionary)

Definition 2

A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. (NCI Thesaurus)

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