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TAK1-Binding Protein 1
Encoded by MAP3K7IP1 Gene, ubiquitous 504-amino acid 54.6-kD TAK1-Binding Protein 1 is a MAP3K responsible for mediation of TGF-beta receptor signals and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)
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