Health / Medical Topics

    Tanespimycin

    Pronunciation

    Definition 1

    A substance being studied in the treatment of cancer. It is made from an antibiotic called geldanamycin. Tanespimycin helps cause the breakdown of certain proteins in the cell, and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of HSP90 inhibitor. Also called 17-AAG and 17-N-allylamino-17-demethoxygeldanamycin. (NCI Dictionary)

    Definition 2

    A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. (NCI Thesaurus)




    YOU MAY ALSO LIKE

    A substance being studied in the treatment of some types of cancer. It may stop cancer cell growth by blocking certain…
    An inherited polymorphism in eukaryotic DNA that results from variations in the number of tandem repeat nucleotide sequences, which are end-to-end adjacent…
    A software program that compares the mass of peptide fragments found by tandem mass spectrometry with the expected peptides based on the…
    Mass spectrometers coupled in series. The targeted compound is selectively ionized, and its characteristic ions are separated from others in the…
    An internal radiation treatment technique in which a small metal tube filled with a radioactive source is placed inside the uterus for…
    A yellowish-brownish color.

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact