| Health / Medical Topics |
TANK-Binding Kinase 1
Encoded by human TBK1 Gene, 729-aa 84-kDa TANK-Binding Kinase 1 (similar to IKB kinases) mediates NFKB activation in response to certain growth factors. TBK1 forms a complex with TRAF2 and TANK IKB protein to release NFKB inhibition by TANK. NFKB complex is inhibited by IKB proteins, which trap it in the cytoplasm. IKB serine phosphorylation by IKB kinases marks them for ubiquitinated destruction, allowing NFKB activation and nuclear translocation. (NCI Thesaurus)
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