Health / Medical Topics |
TARDBP wt Allele
Human TARDBP wild-type allele is located in the vicinity of 1p36.22 and is approximately 13 kb in length. This allele, which encodes TAR DNA-binding protein 43, plays a role in the mediation of both mRNA splicing and DNA transcription. Mutation of the gene is associated with amyotrophic lateral sclerosis type 10. (NCI Thesaurus)
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TAR DNA-binding protein 43 (414 aa, ~45 kDa) is encoded by the human TARDBP gene. This protein is involved in the regulation…