| Health / Medical Topics |
TAX Gene
The genes coding for the Trans-Activator X (tax) protein of HTLV-I and II. Tax activates transcription via interactions with the ATF/CREB transactivator(s) and the CBP/p300 coactivators which assemble as a multiprotein complex on the 21-bp repeat elements in the proviral LTR. Tax also modulates expression of cellular genes via the ATF/CREB and NF-kappaB pathways. (NCI Thesaurus)
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