| Health / Medical Topics |
Taxane-Pocket Binding Agent
Any of a class of anti-mitotic compounds that bind to the taxane site of the beta-tubulin subunit, a region described as a binding pocket located within the middle domain and corresponding to an approximate residue sequence of 217-231. Specifically, these agents bind to a cysteine residue within the pocket, which is also the binding site for GTP. Agents binding at the taxane site promote the polymerization of dimers to form a very rigid and stable microtubule structure which is not readily disassembled. By interfering with microtubule dynamics these agents inhibit the normal turnover process essential during mitosis, thereby causing cell-cycle arrest and/or apoptosis. (NCI Thesaurus)
YOU MAY ALSO LIKE
A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move…
A synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule…
A type of drug that blocks cell growth by stopping mitosis (cell division). Taxanes interfere with microtubules (cellular structures that help move…
Tax Interaction Protein 40, encoded by the PARD6A gene, belongs to the PAR6 family. It is an adapter protein involved in asymetrical…
The genes coding for the Trans-Activator X (tax) protein of HTLV-I and II. Tax activates transcription via interactions with the ATF/CREB…
A charge against a citizen's person or property or activity for the support of government.
