Health / Medical Topics

    TBP Inhibitor Gene

    The assembly of transcription complexes at eukaryotic promoters involves a number of distinct steps, including chromatin remodeling and recruitment of a TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these stages is controlled by positive and negative factors that regulate the interactions of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might depend in part on competition between TBP inhibitors and the holoenzyme for access to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators. (from PMID 10974559) (NCI Thesaurus)




    YOU MAY ALSO LIKE

    This gene plays an essential role in RNA polymerase II transcription and initiation.
    Human TBL2 wild-type allele is located in the vicinity of 7q11.23 and is approximately 10 kb in length. This allele, which encodes…
    This gene may be involved in signaling.
    Human TBL1XR1 wild-type allele is located in the vicinity of 3q26.32 and is approximately 186 kb in length. This allele, which encodes…
    This gene is involved in transcriptional activation.
    Human TBK1 wild-type allele is located in the vicinity of 12q14.1 and is approximately 50 kb in length. This allele, which encodes…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact