Health / Medical Topics

    Technetium Tc-99m Demobesin-4

    Definition 1

    A radioconjugate composed of the synthetic bombesin (BB) analog demobesin-4 bound to the radioisotope technetium Tc 99m with receptor ligand and gamma-emitting radioisotope activities. Upon intravenous administration, demobesin-4 selectively binds to the gastrin-releasing peptide receptor (GRPR) expressed on the surfaces of various tumor cell types; upon internalization, tumor cells expressing GRPRs bound to technetium Tc 99m can then be visualized using scintigraphy. GRPR, a bombesin receptor subtype, is frequently overexpressed on the surface of tumor cells such as prostate and breast cancer cells. Demobesin-4 was developed for technetium Tc 99m imaging of GRPR-expressing tumor cells. (NCI Thesaurus)

    Definition 2

    A substance being studied as a way to find certain types of cancer. It contains a radioactive substance called technetium linked to another substance called demobesin. Demobesin binds to the receptor for bombesin (a substance that is found at higher-than-normal levels on some types of cancer cells). Technetium Tc 99m demobsin-4 collects in cancer cells and a machine is used to find where the cancer cells are in the body. It is a type of radiopharmaceutical and a type of radioimaging agent. (NCI Dictionary)




    YOU MAY ALSO LIKE

    A radioconjugate comprised of the small peptide apcitide labeled with the gamma-emitting technetium TC99m (metastable Tc-99). Apcitide binds to platelet glycoprotein (GP)…
    An injectable radiopharmaceutical formulation containing human serum albumin (HSA) labeled with technetium-99m (Tc99m) in macroaggregates (MAA) with diagnostic imaging activity. Technetium Tc…
    One of the radioactive isotopes of technetium, a gamma/beta-emitter with a half life of 6 hours.
    A substance being studied as a way to find cancer in the body. It is also used to find sentinel lymph nodes…
    An injectable radiopharmaceutical formulation containing human serum albumin (HSA) microspheres labeled with Technetium-99m (Tc-99m) with diagnostic imaging activity. Technetium Tc 99m-labeled albumin…
    A substance being studied as a way to find sentinel lymph nodes in some types of skin cancer and breast cancer. It…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact