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Teniposide
Pronunciation
Definition 1
An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors. (NCI Dictionary)
Definition 2
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI Thesaurus)
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