Health / Medical Topics

    Terameprocol

    Definition 1

    A synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In virally-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2), survivin, and vascular endothelial growth factor (VEGF), which are overexpressed in a variety of cancers. By suppressing Sp1-regulated transcription of these genes, terameprocol may reduce tumor angiogenesis and tumor cell proliferation and induce tumor cell apoptosis. (NCI Thesaurus)

    Definition 2

    A substance being studied in the treatment of cancer. It blocks proteins needed for cancer growth. It is a type of transcriptional inhibitor. (NCI Dictionary)




    YOU MAY ALSO LIKE

    A unit of frequency equal to 10E12 hertz.
    Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of 10^12 international unit per one liter of system…
    A prefix indicating a quantity of one trillion, 10E12.
    Human TEP1 wild-type allele is located in the vicinity of 14q11.2 and is approximately 46 kb in length. This allele, which encodes…
    This gene plays a role in telomerase activity.
    3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic…

    © 1991-2023 The Titi Tudorancea Bulletin | Titi Tudorancea® is a Registered Trademark | Terms of use and privacy policy
    Contact