Tert Regulation Pathway

Telomerase is an enzyme that replicates the terminal sequences of eukaryotic chromosomes, namely the telomeres. Cells that have an unlimited replicative capacity, such as male germ cells and the majority of human cancers, have high levels of telomerase activity. The level and frequency of telomerase activity in more than 85% of all cancers highlights the critical role telomerase plays in tumor progression. Telomerase activation is the most common general marker for a cancer cell to date making it an attractive target for new cancer diagnostics and therapeutics. Human telomerase activity can be reconstituted in vitro by the essential RNA subunit, hTERC, and the catalytic protein component coded for by the hTERT gene. Both the human telomerase reverse transcriptase gene (hTERT) and the telomerase RNA gene (hTERC) are controlled at least in part at the transcriptional level. The hTERT gene is expressed at low levels in cancer cells and is generally undetectable in normal cells. (NCI Thesaurus/BIOCARTA)

YOU MAY ALSO LIKE

TERT Gene

This gene is involved in cell cycle regulation and telomere maintenance.

Territory

A geographical area under the jurisdiction of a sovereign state and marked off for administrative or other purposes.

Terrifying Pain

A sensation of discomfort or distress that is frightening or scary.

Terrier Breed

The Terrier Group includes energetic dogs whose sizes range from fairly small, as in the Norfolk, Cairn or West Highland White Terrier,…

Terpene Compound

The class of compound known as terpenes comprise of essential oils, flavours and fragrances. The extraction and synthesis of compounds such as…

Terpene

A type of strong-smelling chemical substance found in some plants, especially trees that have cones. Terpenes are found in essential oils (scented…