Tezacitabine Anhydrous

The anhydrous form of tezacitabine, a synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and eventually tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, thereby further inhibiting DNA replication. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates, a necessary step for DNA synthesis, and is overexpressed in many tumor cell types. (NCI Thesaurus)

YOU MAY ALSO LIKE

Tezacitabine

A synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate…

Texture Descriptor

A description of the consistency findings or features of a sample.

Texture

A measure of the variation of the intensity of a surface, quantifying properties such as smoothness, coarseness, regularity, and resiliency. The term…

Text Line

Text consisting of a row of words written across a page or computer screen.

Text

The words of something written.

Texas

A state in the southern midwest United States. Its capital is Austin.