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Thioguanine
Pronunciation
Definition 1
An anticancer drug that belongs to the family of drugs called antimetabolites. (NCI Dictionary)
Definition 2
A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI Thesaurus)
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