| Health / Medical Topics |
Thomsen-Friedenreich Antigen
A type 1 core O-glycan with potential immunotherapeutic property. Thomsen-Friedenreich (TF) antigen, a galactose disaccharide, is normally O-linked to serine or threonine residue of mucins (MUC1), a transmembrane glycoprotein overexpressed on epithelial cell surface of a variety of tumor cells. The expression of this antigen is associated with tumor cell adhesion, tissue invasion and aggressiveness. When administered in a vaccine formulation, TF antigen may stimulate a cytotoxic T cell response against tumors expressing TF epitope, which may result in a reduction in tumor size. (NCI Thesaurus)
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A natural number greater than thirty-eight and less than forty and the quantity that it denotes.
A natural number greater than twenty-nine and less than thirty-one and the quantity that it denotes.
