Thymic Stromal Lymphopoietin

Widely expressed in heart, liver, testis, prostate, smooth muscle, keratinocytes, epithelia, and lung fibroblasts by human TSLP Gene (B Cell-Stimulating Cytokine Family), 159-aa 18-kDa hemopoietic cytokine Thymic Stromal Lymphopoietin contains a 28-aa signal sequence, 6 conserved cysteines, 2 N-glycosylation sites, and 7 basic C-terminal amino acids (KKRRKRK). TSLP signals through a heterodimeric TSLPR(CRLF2)/IL7R Alpha receptor. Like IL7, TSLP stimulates STAT5 phosphorylation. Dendritic cells (DC) and monocytes coexpress IL7R and TSLPR. TSLP induces release of T cell-attracting chemokines from monocytes, expression of cytokines and costimulatory molecules in DCs, enhances DC maturation, and induces T-cell proliferation. TSLP also inhibits apoptosis in some cells. (NCI Thesaurus)

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