Health / Medical Topics |
Tiagabine Hydrochloride
The hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma-aminobutyric acid (GABA) transporter type 1 (GAT1), which is predominantly localized in presynaptic terminals of neurons thereby preventing the reuptake of GABA by the presynaptic endings. Consequently, this increases the level of available GABA within the synaptic cleft, thereby resulting in prolongation of its inhibitory actions. Tiagabine is effective against maximum electroshock seizures and both limbic and generalized tonic-clonic seizures. (NCI Thesaurus)
YOU MAY ALSO LIKE
Human TIAF1 wild-type allele is located in the vicinity of 17q11.2 and is approximately 18 kb in length. This allele, which encodes…
This gene plays a role in the regulation of apoptosis.
A substance being studied in the treatment of diarrhea caused by infection with Clostridium difficile (a type of bacteria that can grow…
Thyroxine-binding globulin (415 aa, ~46 kDa) is encoded by the human SERPINA7 gene. This protein plays a role in both binding to…
The determination of the amount of thyroxine binding globulin protein present in a sample.
A hormone that is made by the thyroid gland and contains iodine. Thyroxine increases the rate of chemical reactions in cells and…