Tibolone

A synthetic anabolic steroid with estrogenic, androgenic and progestagenic activities. The 3alpha- and 3beta-hydroxy metabolites of tibilone activate estrogenic receptors (ERs) in bone and vaginal tissue leading to a decrease in bone turnover, and decreased vaginal dryness, respectively; derived from the 3beta-hydroxy metabolite, its delta4-isomer activates androgenic receptors (ARs) in the brain and liver and progestogenic receptors (PRs) in endometrial tissue, affecting sexual function, lipid metabolism, and endometrial function, respectively. In breast and endometrial tissue, tibolone metabolites inhibit sulfatase, preventing the conversion of circulating estrone sulfate and estradiol sulfate to estrone and estradiol, respectively; estrogen-mediated effects in the breast and uterus are thus reduced. (NCI Thesaurus)

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Tibialis Cranialis

An extensor muscle in the anterior surface of the tibia.

Tibial Vein

Either of two veins including the anterior and posterior tibial veins.

Tibial Nerve

One of two major branches of the sciatic nerve. It innervates the muscles of the posterior aspect of the lower limb, the…

Tibial Fracture

Traumatic or pathological injury to the tibia in which the continuity of the bone is broken.

Tibial Artery

Any of the tibial arteries including the anterior and posterior tibial arteries and the anterior and posterior recurrent tibial arteries.

Tibial Adamantinoma

An adamantinoma arising from the tibia. The tibia is the site which is more frequently involved by adamantinoma (80-90% of…