| Health / Medical Topics |
Ticarcillin
Definition 1
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal activity. Similar to carbenicillin in action, ticarcillin inactivates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis. (NCI Thesaurus)
Definition 2
An antibiotic derived from penicillin similar to carbenicillin in action. (NLM, Medical Subject Headings)
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