Tigapotide

A synthetic 15-mer peptide corresponding to amino acids 31-45 of the 94-amino acid isoform of human prostate secretory protein (PSP-94) with potential anti-metastasis and anti-angiogenesis activities. PSP-94-derived peptide PCK3145 may inhibit the secretion of the metastasis-related protein matrix metalloproteinase-9 (MMP-9) and its potential binding to its cell surface receptor CD44; may interfere with the vascular endothelial growth factor (VEGF) signaling pathway, resulting in an anti-angiogenesis effect; and may reduce the levels of parathyroid hormone-related protein (PTHrP), decreasing plasma calcium levels. PSP-94, one of three predominant proteins found in seminal fluid, may be down-regulated in prostate cancer, representing a potential survival mechanism for prostate cancer cells. MMP-9 is implicated in the invasion and metastasis of cancer. PTHrP may be expressed by various tumor cell types, resulting in the hypercalcemia of malignancy. (NCI Thesaurus)

YOU MAY ALSO LIKE

TIFF

A bitmap graphics file format utilizing tagged fields.

Tifenazoxide

A thiadiazine derivative with hypoglycemic activity. Like sulfonylureas, tifenazoxide binds to ATP-sensitive inwardly-rectifier potassium Kir6.2/SUR1 (IKATP) channels on the membrane of pancreatic…

TIE1 wt Allele

Human TIE1 wild-type allele is located within 1p34-p33 and is approximately 22 kb in length. This allele, which encodes tyrosine-protein kinase receptor…

TIE1 Gene

This gene plays a regulatory role in angiogenesis.

Tie Container Closure

Line, ribbon, or cord used for fastening, or drawing the container closed.

Tidal Volume

The volume of air moved into and out of the lungs during breathing at rest.