| Health / Medical Topics |
TNF Receptor-Associated Factor 2
TRAF2 is a homo- or (with TRAF1) heterodimer adaptor protein for TNFR1, TNFR2, and CD40 that mediates activation of NFKB. TRAF2 contains a TRAF motif known to bind kinases involved in TRAF-mediated signaling, a Zn RING finger, and cysteine/histidine-rich motifs. E2F1 can down regulate TRAF2 and inhibit anti-apoptotic NFKB signals. (from OMIM 601895 and NCI) (NCI Thesaurus)
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