TNF Receptor-Associated Factor 6

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human TRAF6 Gene (TRAF Family) encodes 522-aa 60-kDa oligomeric adapter protein and signal transducer TNF Receptor-Associated Factor 6, containing a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. In mediating TNFR and Toll/IL-1 family signal transduction to diverse pathways, TRAF6 interacts with TNFRSF5, -11A, -11B, -16 and -17, SRC, PKC zeta, IRAK1, -2, and -3, RIPK2, MAP3K1, -5, and -14, CSK, TRIP, TRAF, TTRAP, PELI1, PELI2, and PELI3. TRAF6 activates IKK in the NF-kappa B pathway in response to proinflammatory cytokines and is involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. (NCI Thesaurus)

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