TNF Receptor Family Protein

Definition 1

Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366) (NCI Thesaurus)

Definition 2

Cell surface receptors that bind tumor necrosis factor and trigger changes which influence the behavior of cells. The two recognized tumor necrosis factor receptors are designated alpha and beta receptors. Both receptors bind both alpha and beta tumor necrosis factors with high affinity, and both are members of the nerve growth factor receptor family. (NLM, Medical Subject Headings)

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