TNFR1 Signaling Pathway

TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. (NCI Thesaurus/BIOCARTA)

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TNFerade

A gene therapy product that is being studied in combination with radiation therapy in the treatment of cancer.

TNFAIP3 wt Allele

Human TNFAIP3 wt allele is located in the vicinity of 6q23 and is approximately 16 kb in length. This allele, which encodes…

TNFAIP3 Gene

This gene may play a role in the regulation of apoptosis.

TNFAIP1 wt Allele

Human TNFAIP1 wild-type allele is located within 17q22-q23 and is approximately 11 kb in length. This allele, which encodes BTB/POZ domain-containing adapter…

TNFAIP1 Gene

This gene plays a role in the regulation of protein ubiquitination.

TNF-related apoptosis-inducing ligand

A cell protein that can attach to certain molecules in some cancer cells and may kill the cells. TNF-related apoptosis-inducing ligand is…