TNFR2 Signaling Pathway

TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (NCI Thesaurus/BIOCARTA)

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TNFR1 Signaling Pathway

TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1+ cell is triggered to…

TNFerade

A gene therapy product that is being studied in combination with radiation therapy in the treatment of cancer.

TNFAIP3 wt Allele

Human TNFAIP3 wt allele is located in the vicinity of 6q23 and is approximately 16 kb in length. This allele, which encodes…

TNFAIP3 Gene

This gene may play a role in the regulation of apoptosis.

TNFAIP1 wt Allele

Human TNFAIP1 wild-type allele is located within 17q22-q23 and is approximately 11 kb in length. This allele, which encodes BTB/POZ domain-containing adapter…

TNFAIP1 Gene

This gene plays a role in the regulation of protein ubiquitination.