Health / Medical Topics

    Tocladesine

    Pronunciation

    Definition 1

    A substance that has been studied as an anticancer drug. It is an analog of a substance that occurs naturally in the body (cyclic adenosine monophosphate). (NCI Dictionary)

    Definition 2

    An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis. (NCI Thesaurus)




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