| Health / Medical Topics |
Toll-Interacting Protein
Encoded by human TOLLIP Gene, 274-aa 30-kDa oligomeric Toll-Interacting Protein, containing a CUE domain, is involved in IL-1 and Toll-like receptor signaling pathways. TOLLIP binds to TLR2 and TLR4/MD2 complex via its C-terminus. Complexed with Ser/Thr kinase IRAK in unstimulated cells, TOLLIP inhibits IRAK phosphorylation and kinase activity. Upon IL-1 signaling, TOLLIP interacts with the IL-1RacP TIR domain in the activated receptor complex (IL-1RI/IL-1RacP/MyD88), recruiting IRAK to the complex. MyD88 triggers IRAK1 autophosphorylation and IRAK1 dissociation. (NCI Thesaurus)
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