Toll-Like Receptor 2

Highly expressed in monocytes, bone marrow, lymph node, and spleen by human TLR2 Gene (TLR Family), 784-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 2 contains a TIR domain and 14 LRR repeats and has a fundamental role in pathogen recognition and activation of innate immunity. Sharing structural and functional similarities, TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production for effective immunity. With LY96, TLR2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (NCI Thesaurus)

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