Toll-Like Receptor 3

Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes by human TLR3 Gene (TLR Family), 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3 contains a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI Thesaurus)

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