Tolmetin

A synthetic non-steroidal anti-inflammatory agent with pyrrole structure, analgesic and antipyretic Tolmetin has a mode of action similar to indomethacin, but is less potent. Used in the treatment of rheumatoid arthritis, it inhibits prostaglandin synthase and decreases production of inflammatory prostaglandin E. (NCI Thesaurus)

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Tolloid-like protein 1 (1013 aa, ~115 kDa) is encoded by the human TLL1 gene. This protein plays a role in both collagen…

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Human TOLLIP wild-type allele is located in the vicinity of 11p15.5 and is approximately 35 kb in length. This allele, which encodes…

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This gene is involved in signal transduction and regulation of protein trafficking.

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Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound…

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The innate immune response responds in a general manner to factors present in invading pathogens. Bacterial factors such as lipopolysaccharides (LPS, endotoxin),…

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