Topical Betulinic Acid

A topical formulation of a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial factors involved in apoptosis, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells. (NCI Thesaurus)

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Topical

On the surface of the body.

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Human TOPBP1 wild-type allele is located in the vicinity of 3q22.1 and is approximately 61 kb in length. This allele, which encodes…

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This gene is involved in DNA replication and apoptosis regulation.

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Human TOP3B wild-type allele is located in the vicinity of 22q11.22 and is approximately 26 kb in length. This allele, which encodes…

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This gene is involved in DNA recombination, cellular aging and the maintenance of genome integrity.